CAS:124655-09-0|Tert-Butyl(3R,5S)-6-hydroxy-3,5-O-isopropyliden-3,5-dihydroxyhexanoat

Introduktionog ansøgningaf CAS 124655-09-0|(4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-eddikesyre 1,1-dimethylethyl Ester

Et nyttigt syntetisk mellemprodukt.

(4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-eddikesyre 1,1-dimethylethyl Ester er en kemoenzymatisk reduktasehæmmer. Det bruges som et mellemprodukt i syntesen af ​​andre lægemidler, såsom lovastatin.

Tert-butylgruppen er chiral og enantioselektiv. Det binder til det aktive sted af HMG CoA reduktase og forhindrer det i at katalysere omdannelsen af ​​HMG CoA til mevalonsyre. Denne hæmning fører til nedsat produktion af kolesterol og andre lipider.

Synonymer:

(4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-eddikesyre 1,1-dimethylethyl Ester;

tert-Butyl (3R,5S)-6-hydroxy-3,5-O-isopropyliden-3,5-dihydroxyhexanoat;

tert-Butyl 2-[(4R,6S)-6-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxan{{9} }yl]acetat;

(4R,6S)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-eddikesyre 1,1-dimethylethyl Ester;

(4R,6S)-6-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-eddikesyre-tert-butylester;

2-[(4R,6S)-6-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl] eddikesyre tert-butylester;

tert-Butyl (4R,6S)-6-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-acetat;

Specifikation afCAS 124655-09-0|(4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-eddikesyre 1,1-dimethylethyl Ester

Package og transportaf Introduktion og anvendelse af CAS 124655-09-0|(4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-eddikesyre 1,1-dimethylethyl Ester

Pakke: 100 g, 500 g, 1 kg, 25 kg, 200 kg, 500 kg

Transport: med kurer / med fly / til søs

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M Soni, J Vardia, N Joshi - Current Green Chemistry, 2017 - ingentaconnect.com

… 1 Lt RBF, ladet 25 g (0.096 mol) (4R-cis)-6Hydroxymethyl-2,2-dimethyl-1,{{10 }}dioxan-4-eddikesyre

syre, og 1,1-dimethylethylester 2 blev opløst i 165 ml methylendichlorid ved …

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