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Introduktionog ansøgningaf CAS-nr.2378-95-2|diethyl-N-[4-(methylamino)benzoyl]-L-glutamat
diethyl N-[4-(methylamino)benzoyl]-L-glutamat er et prodrug, der metaboliseres til (S)-diethyl 2-(4-aminobenzamido)pentandioat, som hæmmer enzymet dihydrofolat reduktase. Dette forhindrer syntesen af tetrahydrofolat, en essentiel cofaktor i syntesen af nukleinsyrer og aminosyrer. Antibiotikummet har vist sig at være aktivt mod bakterier som Mycobacterium tuberculosis og Staphylococcus aureus, men ikke mod pattedyrceller.
Synonymer:
(S)-diethyl 2-(4-(methylamino)benzamido)pentandioat;
diethyl (2S)-2-[[4-(methylamino)benzoyl]amino]pentandioat;
N-(p-methylaminobenzoyl)glutaminsyrediethylester;
diethyl-N-(p-methylaminobenzoyl)-L-glutamat;
(S)-diethyl 2-(4-(methylamino)benzamido)pentandioat;
PN-methylaminobenzoyl glutaminsyrediethylester;
diethyl N-<4-(methylamino)benzoyl>AC1Q63IM;
diethyl-N-[4-(methylamino)benzoyl]-L-glutamat;
diethyl 4-(methylamino)benzoyl-L-glutamat;
diethyl-p-methylaminobenzoyl-L-glutamat;
N-(4-Methylaminobenzoyl)-L-glutaminsyre diethylester;
diethyl-N-(pN-methylaminobenzoyl)glutamat;
ethyl-N-[p-(methylamino)benzoyl]-L-glutamat;
diethyl<4-(N-methylamino)benzoyl>-L-glutamat;
Specifikation af CAS-nr.2378-95-2|diethyl-N-[4-(methylamino)benzoyl]-L-glutamat
|
ARTIKLER |
SPECIFIKATION |
|
CAS |
2378-95-2 |
|
MF |
C17H24N2O5 |
|
MW |
336.38 |
|
Smeltepunkt |
88-89 grad |
|
Massefylde |
1,165±0,06 g/cm3 (forudsagt) |
|
Kogepunkt |
518,3±50,0 grader (forudsagt) |
|
brydningsindeks |
1.536 |
|
Flammepunkt |
450.1ºC |
|
Opbevaring |
Opbevares på et mørkt sted, forseglet i tørt, stuetemperatur |
PAckage og transportaf Introduktion og anvendelse afCAS-nr.2378-95-2|diethyl-N-[4-(methylamino)benzoyl]-L-glutamat
Pakke:0.1g,1g,5g,25g,100g,500g,1kg
Transport: med kurer / med fly / til søs
relaterede artiklerafCAS-nr.2378-95-2|diethyl-N-[4-(methylamino)benzoyl]-L-glutamat
[Syntese af diethyl-N-[p-(methylamino)benzoyl]-L-glutamat].
C Tian, SX Zhou, B Wang, XL Deng, Y Guo… - Beijing da xue xue …, 2008 - europepmc.org
… Brug af diethyl-N-(p-aminobenzoyl)-L-glutamat (2) som udgangsmateriale via en one-pot-proces
af benzylering og methylering er diethyl-N-[p-(methylamino)benzoyl]-L-glutamat (3) …
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